GL1X · GenesisL1 explorer

Ligand · ZF7

ZF7 · (1R,3S,5S)-8-{(1S)-1-[8-(trifluoromethyl)-7-{[(1s,4R)-4-(trifluoromethyl)cyclohexyl]oxy}naphthalen-2-yl]ethyl}-8-azabicyclo[3.2.1]octane-3-carboxylic acid

ZF7, (1R,3S,5S)-8-{(1S)-1-[8-(trifluoromethyl)-7-{[(1s,4R)-4-(trifluoromethyl)cyclohexyl]oxy}naphthalen-2-yl]ethyl}-8-azabicyclo[3.2.1]octane-3-carboxylic acid (C28 H31 F6 N O3, 543.5 g/mol), in the MolNFT structures on GenesisL1: bound in…

Component
ZF7
Formula
C28 H31 F6 N O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

ZF7 in 2 structures; the first of them:

  • 7MFH · Crystal structure of BIO-32546 bound mouse Autotaxin · ZF7 A901 · binds LEU78, TYR82, ILE167, SER169, PHE210, LEU213, TYR214, LEU216 and 12 more
  • 7MFH · Crystal structure of bio-32546 bound mouse autotaxin · ZF7 A901 · binds LEU78, TYR82, ILE167, SER169, PHE210, LEU213, TYR214, ALA217 and 10 more

Residues it binds most

PHE 2, LEU 2, TYR 2, TRP 2, ALA 2, HIS 2, ILE 2, LYS 2, MET 2, SER 2 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • BMA · beta-D-mannopyranose
  • MAN · alpha-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • IOD · Iodide ion
  • EDO · 1,2-ethanediol
  • PEG · Di(hydroxyethyl)ether

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