Ligand · Z74

Z74 · N'-{(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-[(2R)-4-(phenylsulfonyl)piperazin-2-yl]ethyl}-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide

Z74, N'-{(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-[(2R)-4-(phenylsulfonyl)piperazin-2-yl]ethyl}-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide (C34 H42 F2 N4 O5 S, 656.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records…

Component: Z74
Formula: C34 H42 F2 N4 O5 S
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

Z74 in 2 structures; the first of them:

3LPI · Structure of BACE Bound to SCH745132 · Z74 A456 · binds SER71, GLY72, GLN73, GLY74, LEU91, ASP93, GLY95, SER96 and 20 more
3LPI · Structure of bace bound to SCH745132 · Z74 A456 · binds SER71, GLY72, GLN73, GLY74, LEU91, ASP93, GLY95, SER96 and 20 more

Residues it binds most

GLY 4, ILE 4, THR 4, ARG 4, ASP 4, GLN 4, SER 4, TYR 4, LYS 4, LEU 4 (residue and the binding sites it lines).

Found with

TLA · L(+)-tartaric acid

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