Ligand · YF8
YF8 · N-[8-(4-{[(1R,3R,4S)-4-(4-chlorophenyl)-1-methyl-3-{[4-(4-{[4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-(trifluoromethanesulfonyl)benzene-1-sulfonyl]carbamoyl}phenyl)piperazin-1-yl]methyl}cyclohexyl]methyl}piperazin-1-yl)-8-oxooctanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide
YF8, N-[8-(4-{[(1R,3R,4S)-4-(4-chlorophenyl)-1-methyl-3-{[4-(4-{[4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-(trifluoromethanesulfonyl)benzene-1-sulfonyl]carbamoyl}phenyl)piperazin-1-yl]methyl}cyclohexyl]methyl}piperaz…
- Component
- YF8
- Formula
- C82 H104 Cl F3 N11 O11 S4
- Class
- ligand
- Structures
- 1
- PDB entries
- 1
Binding sites
YF8 in 1 structure; the first of them:
- 8FY0 · E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) · YF8 D301 · binds ASN67, ARG69, PHE76, PRO86, TRP88, PHE91, TYR98, PRO99 and 34 more
Residues it binds most
PHE 1, ARG 1, ALA 1, LEU 1, TYR 1, TRP 1, ASN 1, GLU 1, HIS 1, PRO 1 (residue and the binding sites it lines).
Found with
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