GL1X · GenesisL1 explorer

Ligand · XCF

XCF · 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine

XCF, 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine (C19 H22 N4 O3, 354.4 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within…

Component
XCF
Formula
C19 H22 N4 O3
Class
ligand
Structures
10
PDB entries
5

Binding sites

XCF in 10 structures; the first of them:

  • 3FRF · S. aureus DHFR complexed with NADPH and iclaprim · XCF X300 · binds LEU5, VAL6, ALA7, GLN19, LEU20, ASP27, LEU28, VAL31 and 5 more
  • 3FY8 · Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101 · XCF X300 · binds LEU5, VAL6, ALA7, GLN19, LEU20, ASP27, LEU28, VAL31 and 6 more
  • 3FY9 · Staph. aureus DHFR F98Y complexed with AR-102 · XCF X300 · binds LEU5, VAL6, ALA7, GLN19, LEU20, ASP27, LEU28, VAL31 and 6 more
  • 3FYV · Staph. aureus DHFR complexed with NADPH and AR-102 · XCF X300 · binds LEU5, VAL6, ALA7, ASN18, GLN19, LEU20, ASP27, LEU28 and 6 more
  • 3FYW · Staph. aureus DHFR complexed with NADPH and AR-101 · XCF X300 · binds LEU5, VAL6, ALA7, ASN18, GLN19, LEU20, ASP27, LEU28 and 6 more
  • 3FRF · S. aureus DHFR complexed with NADPH and iclaprim · XCF X300 · binds LEU5, VAL6, ALA7, GLN19, LEU20, ASP27, LEU28, VAL31 and 5 more
  • 3FY8 · Crystal structure of staph. aureus DHFR complexed with NADPH and ar- 101 · XCF X300 · binds LEU5, VAL6, ALA7, GLN19, LEU20, ASP27, LEU28, VAL31 and 6 more
  • 3FY9 · Staph. aureus DHFR F98Y complexed with ar-102 · XCF X300 · binds LEU5, VAL6, ALA7, GLN19, LEU20, ASP27, LEU28, VAL31 and 6 more
  • 3FYV · Staph. aureus DHFR complexed with NADPH and ar-102 · XCF X300 · binds LEU5, VAL6, ALA7, ASN18, GLN19, LEU20, ASP27, LEU28 and 6 more
  • 3FYW · Staph. aureus DHFR complexed with NADPH and ar-101 · XCF X300 · binds LEU5, VAL6, ALA7, ASN18, GLN19, LEU20, ASP27, LEU28 and 6 more

Residues it binds most

LEU 10, VAL 10, ALA 10, ASP 10, GLN 10, ILE 10, PHE 10, SER 10, THR 10, ASN 4 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.