Ligand · WRA
WRA · 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine
WRA, 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine (C14 H18 Cl3 N5 O2, 394.7 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its…
- Component
- WRA
- Formula
- C14 H18 Cl3 N5 O2
- Class
- ligand
- Structures
- 6
- PDB entries
- 3
Binding sites
WRA in 6 structures; the first of them:
- 1J3I · Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS)… · WRA A609 · binds ILE14, CYS15, ALA16, LEU46, LYS49, ASP54, MET55, PHE58 and 8 more
- 1J3K · Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate… · WRA A609 · binds ILE14, CYS15, ALA16, LEU46, TRP48, ASP54, MET55, PHE58 and 9 more
- 3RG9 · Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210 · WRA A602 · binds VAL32, VAL33, ALA34, THR46, ILE47, ASP54, MET55, PHE58 and 9 more
- 1J3I · Wild-type plasmodium falciparum dihydrofolate reductase- thymidylate synthase (pfdhfr-ts)… · WRA A609 · binds ILE14, CYS15, ALA16, LEU46, LYS49, ASP54, MET55, PHE58 and 8 more
- 1J3K · Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate… · WRA A609 · binds ILE14, CYS15, ALA16, LEU46, TRP48, ASP54, MET55, PHE58 and 9 more
- 3RG9 · Trypanosoma brucei dihydrofolate reductase (tbdhfr) in complex with WR99210 · WRA A602 · binds VAL32, VAL33, ALA34, THR46, ILE47, ASP54, MET55, PHE58 and 9 more
Residues it binds most
ILE 12, LEU 12, PHE 12, THR 12, ALA 12, ASP 12, MET 12, PRO 12, SER 12, TYR 12 (residue and the binding sites it lines).
Found with
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.