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Ligand · VH4

VH4 · 1-(3-fluorophenyl)-N-[trans-4-(2-hydroxypropan-2-yl) cyclohexyl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

VH4, 1-(3-fluorophenyl)-N-[trans-4-(2-hydroxypropan-2-yl) cyclohexyl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide (C22 H29 F N4 O2, 400.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
VH4
Formula
C22 H29 F N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

VH4 in 2 structures; the first of them:

  • 7JR6 · H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors · VH4 A202 · binds TYR8, PHE9, MET11, GLY13, ARG14, GLN36, ASP96, MET99 and 6 more
  • 7JR6 · H-pdgs complexed with a 2-PHENYLIMIDAZO[1,2-A]PYRIDINE-6-carboxamide inhibitors · VH4 A202 · binds TYR8, MET11, GLY13, ARG14, GLN36, ASP96, MET99, SER100 and 5 more

Residues it binds most

MET 4, TYR 4, ALA 4, ARG 4, ASP 4, GLN 4, GLY 4, LEU 4, SER 4, THR 4 (residue and the binding sites it lines).

Found with

  • GSH · Glutathione
  • MG · Magnesium ion
  • NA · Sodium ion

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