Ligand · VG9
VG9 · 6-{[(2,5-diethoxyphenyl)amino]methyl}-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine
VG9, 6-{[(2,5-diethoxyphenyl)amino]methyl}-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine (C19 H24 N6 O2, 368.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5…
- Component
- VG9
- Formula
- C19 H24 N6 O2
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
VG9 in 4 structures; the first of them:
- 2W3B · Human dihydrofolate reductase complexed with NADPH and a lipophilic antifolate selective… · VG9 A301 · binds ILE7, VAL8, ALA9, GLY20, ASP21, LEU22, GLU30, PHE31 and 11 more
- 2W3W · Mycobacterium avium dihydrofolate reductase complexed with NADPH and a lipophilic… · VG9 A1168 · binds VAL9, TRP10, ALA11, ILE24, ASP31, LEU32, PHE35, LYS36 and 8 more
- 2W3B · Human dihydrofolate reductase complexed with NADPH and a lipophilic antifolate selective… · VG9 A301 · binds ILE7, VAL8, ALA9, GLY20, ASP21, LEU22, GLU30, PHE31 and 11 more
- 2W3W · Mycobacterium avium dihydrofolate reductase complexed with NADPH and a lipophilic… · VG9 A1168 · binds VAL9, TRP10, ALA11, ILE24, ASP31, LEU32, PHE35, LYS36 and 8 more
Residues it binds most
LEU 6, ILE 6, VAL 6, PHE 6, THR 6, ALA 6, ASP 6, PRO 6, TYR 6, ARG 4 (residue and the binding sites it lines).
Found with
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