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Ligand · V1Y

V1Y · 4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide

V1Y, 4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide (C23 H16 Cl F N6 O S, 478.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
V1Y
Formula
C23 H16 Cl F N6 O S
Class
ligand
Structures
2
PDB entries
1

Binding sites

V1Y in 2 structures; the first of them:

  • 6XFP · Crystal Structure of BRAF kinase domain bound to Belvarafenib · V1Y A801 · binds ILE463, VAL471, ALA481, VAL482, LYS483, GLU501, LEU505, ILE513 and 14 more
  • 6XFP · Crystal structure of braf kinase domain bound to belvarafenib · V1Y A801 · binds ILE463, VAL471, ALA481, VAL482, LYS483, GLU501, LEU505, LEU514 and 11 more

Residues it binds most

ILE 2, LEU 2, PHE 2, VAL 2, ALA 2, ASP 2, CYS 2, GLN 2, GLU 2, GLY 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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