Ligand · UWM

UWM · trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutane-1-carbonitrile

UWM, trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutane-1-carbonitrile (C20 H17 N9, 383.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component: UWM
Formula: C20 H17 N9
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

UWM in 2 structures; the first of them:

6X8G · Crystal structure of TYK2 with Compound 22 · UWM A4000 · binds LEU903, GLY904, GLU905, GLY906, GLY909, LYS910, VAL911, ALA928 and 13 more
6X8G · Crystal structure of TYK2 with compound 22 · UWM A4000 · binds LEU903, GLY904, GLU905, GLY906, GLY909, LYS910, VAL911, ALA928 and 13 more

Residues it binds most

GLY 2, LEU 2, GLU 2, LYS 2, VAL 2, ALA 2, ARG 2, ASN 2, ASP 2, ILE 2 (residue and the binding sites it lines).

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