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Ligand · UUL

UUL · 4-{[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino}phenol

UUL, 4-{[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino}phenol (C15 H11 Cl N2 O S, 302.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
UUL
Formula
C15 H11 Cl N2 O S
Class
ligand
Structures
4
PDB entries
2

Binding sites

UUL in 4 structures; the first of them:

  • 3VZC · Crystal structure of Sphingosine Kinase 1 with inhibitor · UUL A1001 · binds PHE173, ILE174, VAL177, ASP178, PHE192, THR196, LEU259, LEU261 and 10 more
  • 3VZD · Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP · UUL A401 · binds PHE173, ILE174, VAL177, ASP178, PHE192, THR196, LEU259, LEU261 and 10 more
  • 3VZC · Crystal structure of sphingosine kinase 1 with inhibitor · UUL A1001 · binds PHE173, ILE174, VAL177, ASP178, PHE192, THR196, LEU259, LEU261 and 10 more
  • 3VZD · Crystal structure of sphingosine kinase 1 with inhibitor and ADP · UUL A401 · binds PHE173, ILE174, VAL177, ASP178, PHE192, THR196, LEU259, LEU261 and 10 more

Residues it binds most

LEU 26, PHE 26, MET 24, ALA 26, ASP 24, HIS 24, ILE 24, THR 24, VAL 24, ARG 2 (residue and the binding sites it lines).

Found with

  • ADP · Adenosine-5'-diphosphate
  • POP · Pyrophosphate 2-
  • MG · Magnesium ion
  • CL · Chloride ion
  • EDO · 1,2-ethanediol

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