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Ligand · TRH

TRH · 2'-deoxy-thymidine-beta-L-rhamnose

TRH, 2'-deoxy-thymidine-beta-L-rhamnose (C16 H26 N2 O15 P2, 548.3 g/mol), in the MolNFT structures on GenesisL1: bound in 7 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
TRH
Formula
C16 H26 N2 O15 P2
Class
ligand
Structures
7
PDB entries
6

Binding sites

TRH in 7 structures; the first of them:

  • 5IFY · Crystal structure of Glucose-1-phosphate thymidylyltransferase from Burkholderia… · TRH A500 · binds LEU8, ALA9, GLY10, GLY11, GLN26, GLN82, PRO85, ASP86 and 17 more
  • 6J7K · Crystal structure of Pseudomonas aeruginosa Earp in complex with TDP-Rha · TRH A401 · binds ASN13, TYR14, GLY15, ASP16, GLY18, ILE48, TYR112, PHE190 and 12 more
  • 5NV8 · Structural basis for earp-mediated arginine glycosylation of translation elongation… · TRH A401 · binds ASP13, TYR15, GLY16, ASP17, GLY19, PHE191, TYR193, PRO217 and 10 more
  • 5WXI · Earp bound with dtdp-rhamnose (soaked) · TRH A401 · binds ILE15, PHE18, GLY19, ASP20, LEU52, TYR115, PHE185, TYR187 and 12 more
  • 5XVR · Earp bound with dtdp-rhamnose (co-crystal) · TRH A401 · binds PHE18, GLY19, ASN20, LEU52, TYR115, PHE185, TYR187, ALA211 and 11 more
  • 6J7K · Crystal structure of pseudomonas aeruginosa earp in complex with tdp- rha · TRH A401 · binds ASN13, TYR14, GLY15, ASP16, GLY18, ILE48, TYR112, PHE190 and 12 more
  • 6N0U · Crystal structure of a glucose-1-phosphate thymidylyltransferase from burkholderia… · TRH A500 · binds LEU8, GLY10, GLY11, GLN26, GLN82, PRO85, ASP86, GLY87 and 17 more

Residues it binds most

GLY 17, TYR 17, ASP 17, LEU 14, GLN 17, GLU 17, PHE 7, ARG 16, THR 10, PRO 17 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • MES · 2-(N-morpholino)-ethanesulfonic acid
  • UMP · 2'-deoxyuridine 5'-monophosphate
  • BME · Beta-mercaptoethanol
  • EDO · 1,2-ethanediol
  • GOL · Glycerol

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