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Ligand · TMK

TMK · (6M)-N-(3-chloro-2-methoxy-5-methylpyridin-4-yl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide

TMK, (6M)-N-(3-chloro-2-methoxy-5-methylpyridin-4-yl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide (C21 H21 Cl F4 N6 O5, 548.9 g/mol), in the…

Component
TMK
Formula
C21 H21 Cl F4 N6 O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

TMK in 2 structures; the first of them:

  • 8DHH · Dhodh in complex with ligand 29 · TMK A403 · binds TYR38, LEU42, MET43, LEU46, GLN47, LEU50, PRO52, ALA55 and 17 more
  • 8DHH · Dhodh in complex with ligand 29 · TMK A403 · binds TYR38, LEU42, MET43, LEU46, GLN47, LEU50, PRO52, ALA55 and 15 more

Residues it binds most

LEU 2, ALA 2, PHE 2, PRO 2, THR 2, TYR 2, VAL 2, MET 2, ARG 2, GLN 2 (residue and the binding sites it lines).

Found with

  • FMN · Flavin mononucleotide
  • ORO · Orotic acid
  • SO4 · Sulfate ion
  • ACT · Acetate ion
  • GOL · Glycerol

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