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Ligand · TLM

TLM · Thiolactomycin

TLM, Thiolactomycin (C11 H14 O2 S, 210.3 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
TLM
Formula
C11 H14 O2 S
Class
ligand
Structures
10
PDB entries
5

Binding sites

TLM in 10 structures; the first of them:

  • 1FJ4 · The structure of beta-ketoacyl-[acyl carrier protein] synthase I in complex with… · TLM A500 · binds CYS163, PHE229, ASP268, MET269, VAL270, ALA271, PRO272, HIS298 and 9 more
  • 2VB8 · beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin · TLM A1405 · binds CYS163, PHE229, ASP265, ASP268, MET269, VAL270, ALA271, PRO272 and 10 more
  • 2WGE · Crystal structure of KasA of Mycobacterium tuberculosis with bound TLM · TLM A1424 · binds CYS171, PHE237, ASP273, VAL278, ALA279, PRO280, HIS311, THR313 and 10 more
  • 2WGG · Crystal Structure of Mycobacterium tuberculosis C171Q KasA variant with bound TLM · TLM A1417 · binds GLN171, PHE237, HIS276, MET277, VAL278, ALA279, PRO280, HIS311 and 9 more
  • 4C6X · Crystal structure of M. tuberculosis C171Q KasA in complex with thiolactomycin (TLM) · TLM A1419 · binds GLN171, PHE237, HIS276, MET277, VAL278, ALA279, PRO280, HIS311 and 9 more
  • 1FJ4 · The structure of beta-ketoacyl-[acyl carrier protein] synthase I in complex with… · TLM A500 · binds CYS163, PHE229, ASP268, MET269, VAL270, ALA271, PRO272, HIS298 and 9 more
  • 2VB8 · Beta-ketoacyl-acp synthase I (kas) from E. COLI with bound inhibitor thiolactomycin · TLM A1405 · binds CYS163, PHE229, ASP265, ASP268, MET269, VAL270, ALA271, PRO272 and 10 more
  • 2WGE · Crystal structure of kasa of mycobacterium tuberculosis with bound tlm · TLM A1424 · binds CYS171, PHE237, ASP273, VAL278, ALA279, PRO280, HIS311, THR313 and 10 more
  • 2WGG · Crystal structure of mycobacterium tuberculosis C171Q kasa variant with bound tlm · TLM A1417 · binds GLN171, PHE237, HIS276, MET277, VAL278, ALA279, PRO280, HIS311 and 9 more
  • 4C6X · Crystal structure of M. tuberculosis C171Q kasa in complex with thiolactomycin (tlm) · TLM A1419 · binds GLN171, PHE237, HIS276, MET277, VAL278, ALA279, PRO280, HIS311 and 9 more

Residues it binds most

GLY 38, PHE 38, HIS 38, THR 38, ALA 38, PRO 38, VAL 38, MET 36, ASP 20, GLN 20 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion
  • M7U · (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate
  • K · Potassium ion
  • CL · Chloride ion
  • 2PE · Nonaethylene glycol
  • EDO · 1,2-ethanediol
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
  • GOL · Glycerol
  • IPA · Isopropyl alcohol
  • PEG · Di(hydroxyethyl)ether

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