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Ligand · SFR

SFR · (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid

SFR, (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid (C12 H17 N O6 S, 303.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site…

Component
SFR
Formula
C12 H17 N O6 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

SFR in 4 structures; the first of them:

  • 5UJ4 · Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed faropenem · SFR A301 · binds SER70, LYS73, TRP105, SER130, ASN132, GLU166, LEU167, ASN170 and 6 more
  • 6KGT · Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis… · SFR A701 · binds GLY385, SER386, ALA424, SER441, ASN443, THR578, LYS592, THR593 and 2 more
  • 5UJ4 · Crystal structure of the kpc-2 beta-lactamase complexed with hydrolyzed faropenem · SFR A301 · binds SER70, LYS73, TRP105, SER130, ASN132, GLU166, LEU167, THR216 and 5 more
  • 6KGT · Crystal structure of penicillin binding protein 3 (PBP3) from mycobacterium tuerculosis… · SFR A701 · binds GLY385, SER386, ALA424, SER441, ASN443, THR578, LYS592, THR593 and 2 more

Residues it binds most

THR 4, SER 4, GLY 4, LYS 4, ASN 4, ALA 2, ARG 2, GLU 2, LEU 2, TRP 2 (residue and the binding sites it lines).

Found with

  • CO · Cobalt (II) ion
  • GOL · Glycerol

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