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Ligand · FPM

FPM · (5R,6S)-6-(1-hydroxyethyl)-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

FPM, (5R,6S)-6-(1-hydroxyethyl)-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (C12 H15 N O5 S, 285.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site…

Component
FPM
Formula
C12 H15 N O5 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

FPM in 4 structures; the first of them:

  • 3BFF · class A beta-lactamase SED-G238C complexed with faropenem · FPM C1 · binds LYS94, MET95, THR96, LYS137, ALA140, HIS141
  • 4HKY · New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Faropenem · FPM A301 · binds TRP93, HIS122, GLN123, ASP124, HIS189, CYS208, LYS211, LEU218 and 3 more
  • 3BFF · Class a beta-lactamase sed-G238C complexed with faropenem · FPM C1 · binds LYS94, MET95, THR96, LYS137, ALA140, HIS141
  • 4HKY · New delhi metallo-beta-lactamase-1, complexed with CD and faropenem · FPM A301 · binds TRP93, HIS122, GLN123, ASP124, HIS189, CYS208, LYS211, LEU218 and 3 more

Residues it binds most

HIS 6, LYS 6, ASN 4, ASP 4, CYS 4, GLN 4, GLY 4, LEU 4, TRP 4, ALA 2 (residue and the binding sites it lines).

Found with

  • SFR · (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid
  • CD · Cadmium ion
  • CL · Chloride ion
  • SCN · Thiocyanate ion
  • GOL · Glycerol

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