GL1X · GenesisL1 explorer

Ligand · QWK

QWK · ~{N}-[6-(phenylmethyl)-7,8-dihydro-5~{H}-pyrido[4,3-d]pyrimidin-2-yl]propanamide

QWK, ~{N}-[6-(phenylmethyl)-7,8-dihydro-5~{H}-pyrido[4,3-d]pyrimidin-2-yl]propanamide (C17 H20 N4 O, 296.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
QWK
Formula
C17 H20 N4 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

QWK in 2 structures; the first of them:

  • 7A1W · KRASG12C GDP form in complex with Cpd3 · QWK A204 · binds CYS12, PRO34, THR35, ALA59, GLU62, GLU63, TYR64, MET67
  • 7A1W · KRASG12C GDP form in complex with CPD3 · QWK A204 · binds CYS12, PRO34, THR35, ALA59, GLU62, GLU63, TYR64, MET67

Residues it binds most

CYS 4, GLU 2, ALA 2, ASP 2, GLN 2, MET 2, PRO 2, SER 2, THR 2, TYR 2 (residue and the binding sites it lines).

Found with

  • GDP · Guanosine-5'-diphosphate
  • MG · Magnesium ion
  • PO4 · Phosphate ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.