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Ligand · PVX

PVX · N-(2-amino-5-{formyl[(6as,8r,9r,9ar)-9-hydroxy-4-methoxy-1,11-dioxo-1,6A,8,9,9A,11-hexahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromen-8-yl]amino}-6-oxo-1,6-dihydropyrimidin-4-yl)-2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosylamine

PVX, N-(2-amino-5-{formyl[(6as,8r,9r,9ar)-9-hydroxy-4-methoxy-1,11-dioxo-1,6A,8,9,9A,11-hexahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromen-8-yl]amino}-6-oxo-1,6-dihydropyrimidin-4-yl)-2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl…

Component
PVX
Formula
C27 H26 N5 O15 P
Class
ligand
Structures
3
PDB entries
3

Binding sites

PVX in 3 structures; the first of them:

  • 3PVX · Binary complex of aflatoxin B1 adduct modified DNA (AFB1-fapy) with DNA polymerase IV · PVX B374 · binds GLY246, ARG247, ILE248, LYS275, ILE295, ARG332, DT373, DA375 and 2 more
  • 3PW0 · Ternary complex of aflatoxin B1 adduct modified DNA (AFB1-fapy) with DNA polymerase IV… · PVX B374 · binds VAL32, ARG247, ILE248, VAL249, THR250, ILE295, ARG332, DT373 and 3 more
  • 3PW2 · Ternary complex of aflatoxin B1 adduct modified DNA (AFB1-fapy) with DNA polymerase IV… · PVX B374 · binds TYR13, LYS79, GLY247, ARG248, ILE249, LYS276, DT373, DA375 and 2 more

Residues it binds most

DT 3, ARG 3, ILE 3, DA 3, DC 3, LYS 2, GLY 2, VAL 1, THR 1, TYR 1 (residue and the binding sites it lines).

Found with

  • CA · Calcium ion
  • DTP · 2'-deoxyadenosine 5'-triphosphate
  • TTP · Thymidine-5'-triphosphate

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