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Ligand · PLU

PLU · Leucine phosphonic acid

PLU, Leucine phosphonic acid (C5 H14 N O3 P, 167.1 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with…

Component
PLU
Formula
C5 H14 N O3 P
Class
ligand
Structures
10
PDB entries
5

Binding sites

PLU in 10 structures; the first of them:

  • 1FT7 · Aap complexed with L-leucinephosphonic acid · PLU A500 · binds HIS97, ASP117, GLU151, GLU152, ASP179, MET180, CYS223, TYR225 and 7 more
  • 1LCP · Bovine lens leucine aminopeptidase complexed with L-leucine phosphonic acid · PLU A500 · binds LYS250, ASP255, LYS262, MET270, ASP273, ASP332, GLU334, GLY335 and 5 more
  • 3B3C · Crystal structure of the M180A mutant of the aminopeptidase from Vibrio proteolyticus in… · PLU A500 · binds HIS97, ASP117, GLU151, GLU152, ASP179, CYS223, TYR225, CYS227 and 6 more
  • 3B7I · Crystal structure of the S228A mutant of the aminopeptidase from Vibrio proteolyticus in… · PLU A500 · binds HIS97, ASP117, GLU151, GLU152, ASP179, MET180, CYS223, TYR225 and 8 more
  • 4PU2 · Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of… · PLU A901 · binds GLN115, GLU117, PHE254, MSE256, ALA258, MSE259, GLU260, HIS293 and 6 more
  • 1FT7 · Aap complexed with L-leucinephosphonic acid · PLU A500 · binds HIS97, ASP117, GLU151, GLU152, ASP179, MET180, CYS223, TYR225 and 7 more
  • 1LCP · Bovine lens leucine aminopeptidase complexed with L-leucine phosphonic acid · PLU A500 · binds LYS250, ASP255, LYS262, MET270, ASP273, ASP332, GLU334, GLY335 and 5 more
  • 3B3C · Crystal structure of the M180A mutant of the aminopeptidase from vibrio proteolyticus in… · PLU A500 · binds HIS97, ASP117, GLU151, GLU152, ASP179, CYS223, TYR225, CYS227 and 6 more
  • 3B7I · Crystal structure of the S228A mutant of the aminopeptidase from vibrio proteolyticus in… · PLU A500 · binds HIS97, ASP117, GLU151, GLU152, ASP179, MET180, CYS223, TYR225 and 8 more
  • 4PU2 · Crystal structure of aminopeptidase N in complex with the phosphonic acid analogue of… · PLU A901 · binds GLN115, GLU117, PHE254, MSE256, ALA258, MSE259, GLU260, HIS293 and 6 more

Residues it binds most

ASP 10, GLU 12, HIS 8, TYR 8, MET 10, PHE 8, CYS 6, LYS 6, ALA 8, GLY 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • K · Potassium ion
  • NA · Sodium ion
  • SCN · Thiocyanate ion
  • LEU · Leucine
  • SO4 · Sulfate ion
  • GOL · Glycerol
  • MRD · (4R)-2-methylpentane-2,4-diol

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