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Ligand · P2H

P2H · 1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium

P2H, 1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium (C13 H16 N O7 P2 +1, 360.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
P2H
Formula
C13 H16 N O7 P2 +1
Class
ligand
Structures
4
PDB entries
2

Binding sites

P2H in 4 structures; the first of them:

  • 3ICM · Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with isopentenyl… · P2H A363 · binds TYR94, LEU95, ASP98, MET101, ASP102, ARG107, THR163, GLN167 and 8 more
  • 4JZB · Crystal Structure of Leshmaniasis major Farnesyl diphosphate synthase in complex with… · P2H A405 · binds PHE94, LEU95, ASP98, MET101, ASP102, ARG107, THR163, GLN167 and 9 more
  • 3ICM · Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with isopentenyl… · P2H A363 · binds TYR94, LEU95, ASP98, MET101, ASP102, ARG107, THR163, GLN167 and 8 more
  • 4JZB · Crystal structure of leshmaniasis major farnesyl diphosphate synthase in complex with… · P2H A405 · binds PHE94, LEU95, ASP98, MET101, ASP102, ARG107, THR163, GLN167 and 9 more

Residues it binds most

ASP 6, GLN 6, LYS 6, THR 6, TYR 6, ARG 6, LEU 6, MET 6, ASN 4, PHE 4 (residue and the binding sites it lines).

Found with

  • IPE · 3-methylbut-3-enyl trihydrogen diphosphate
  • CA · Calcium ion
  • MG · Magnesium ion
  • NA · Sodium ion
  • SO4 · Sulfate ion

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