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Ligand · P2G

P2G · (2s,4r,6r,6as)-4-(2-amino-6-oxo-1,6-dihydropurin-9-yl)-6-(hydroxymethyl)-tetrahydrofuro[3,4-d][1,3]dioxol-2-ylphosphoni C acid

P2G, (2s,4r,6r,6as)-4-(2-amino-6-oxo-1,6-dihydropurin-9-yl)-6-(hydroxymethyl)-tetrahydrofuro[3,4-d][1,3]dioxol-2-ylphosphoni C acid (C11 H14 N5 O8 P, 375.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries).…

Component
P2G
Formula
C11 H14 N5 O8 P
Class
ligand
Structures
4
PDB entries
2

Binding sites

P2G in 4 structures; the first of them:

  • 2AI3 · Purine nucleoside phosphorylase from calf spleen · P2G A293 · binds GLY32, SER33, ARG84, HIS86, ASN115, ALA116, ALA117, GLY118 and 13 more
  • 4GUK · New crystal form structure of human NCS1 · P2G C206 · binds THR87, LYS95, TRP98, LEU102, LEU176
  • 2AI3 · Purine nucleoside phosphorylase from calf spleen · P2G A293 · binds GLY32, SER33, ARG84, HIS86, ASN115, ALA116, ALA117, GLY118 and 13 more
  • 4GUK · New crystal form structure of human NCS1 · P2G C206 · binds THR87, LYS95, TRP98, LEU102, LEU176

Residues it binds most

LEU 10, ALA 6, THR 8, GLY 2, LYS 6, TRP 6, VAL 2, ASN 2, HIS 2, MET 4 (residue and the binding sites it lines).

Found with

  • ALA · Alanine
  • P3G · 3,6,9,12,15-pentaoxaheptadecane
  • CA · Calcium ion
  • MG · Magnesium ion
  • NA · Sodium ion
  • ZN · Zinc ion
  • 144 · Tris-hydroxymethyl-methyl-ammonium
  • EDO · 1,2-ethanediol
  • PG4 · Tetraethylene glycol

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