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Ligand · P1Z

P1Z · 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione

P1Z, 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione (C19 H20 N2 O2, 308.4 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
P1Z
Formula
C19 H20 N2 O2
Class
ligand
Structures
9
PDB entries
5

Binding sites

P1Z in 9 structures; the first of them:

  • 2BXC · Human serum albumin complexed with phenylbutazone · P1Z A2001 · binds TYR150, GLU153, SER192, GLN196, LYS199, LEU219, ARG222, PHE223 and 9 more
  • 2BXP · Human serum albumin complexed with myristate and phenylbutazone · P1Z A3001 · binds PHE211, TRP214, ARG218, LEU219, PHE223, LEU234, LEU238, HIS242 and 7 more
  • 2BXQ · Human serum albumin complexed with myristate, phenylbutazone and indomethacin · P1Z A2002 · binds LYS199, PHE211, LEU219, ARG222, PHE223, LEU238, HIS242, ARG257 and 6 more
  • 2W98 · Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary… · P1Z A1351 · binds ASP49, TYR51, THR62, TYR64, ILE65, PHE99, MET135, CYS253 and 7 more
  • 8HCK · NMR fragment-based screening against the two PDZ do-mains of MDA-9 · P1Z A101 · binds GLY11, LYS12, ILE13, GLY14, LEU15, ARG16, GLN30, HIS63 and 2 more
  • 2BXC · Human serum albumin complexed with phenylbutazone · P1Z A2001 · binds TYR150, GLU153, SER192, GLN196, LYS199, LEU219, ARG222, PHE223 and 9 more
  • 2BXP · Human serum albumin complexed with myristate and phenylbutazone · P1Z A3001 · binds PHE211, TRP214, ARG218, LEU219, PHE223, LEU234, LEU238, HIS242 and 7 more
  • 2BXQ · Human serum albumin complexed with myristate, phenylbutazone and indomethacin · P1Z A2002 · binds LYS199, PHE211, LEU219, ARG222, PHE223, LEU238, HIS242, ARG257 and 6 more
  • 2W98 · Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary… · P1Z A1351 · binds ASP49, TYR51, THR62, TYR64, ILE65, PHE99, MET135, CYS253 and 7 more

Residues it binds most

LEU 23, TYR 14, PHE 20, ILE 17, ARG 13, LYS 13, ALA 8, GLU 8, SER 8, MET 10 (residue and the binding sites it lines).

Found with

  • MYR · Myristic acid
  • IMN · Indomethacin
  • LMR · (2S)-2-hydroxybutanedioic acid
  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate
  • NA · Sodium ion
  • CL · Chloride ion
  • PO4 · Phosphate ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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