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Ligand · ORU

ORU · 5-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-1,3-thiazole

ORU, 5-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-1,3-thiazole (C23 H18 Cl F N8 O S, 509.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
ORU
Formula
C23 H18 Cl F N8 O S
Class
ligand
Structures
2
PDB entries
1

Binding sites

ORU in 2 structures; the first of them:

  • 7V14 · Factor XIa in Complex with Compound 2h · ORU A702 · binds ARG413, HIS414, LEU415, CYS416, HIS431, CYS432, TYR521, LEU524 and 17 more
  • 7V14 · Factor xia in complex with compound 2H · ORU A702 · binds ARG413, CYS416, HIS431, TYR521, LEU524, ILE528, ASP569, ALA570 and 14 more

Residues it binds most

GLY 2, CYS 2, ASP 2, SER 2, TYR 2, HIS 2, LEU 2, ALA 2, ARG 2, ILE 2 (residue and the binding sites it lines).

Found with

  • CIT · Citric acid

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