OK8 · (2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid

Binding sites

OK8 in 6 structures; the first of them:

• 6YB8 · Human octameric PAICS in complex with CAIR and SAICAR · OK8 A502 · binds LYS17, THR40, ALA41, GLY42, ASN43, GLU97, VAL99, ARG101 and 14 more
• 6YB9 · Human octameric PAICS in complex with SAICAR, AMP-PNP, and magnesium · OK8 A502 · binds LYS17, THR40, ALA41, GLY42, GLU97, VAL99, ARG101, THR105 and 14 more
• 7ALE · Crystal structure of human PAICS in complex with inhibitor 69 · OK8 A502 · binds LYS17, THR18, THR40, ALA41, GLY42, GLU97, VAL99, ARG101 and 15 more
• 6YB8 · Human octameric paics in complex with cair and saicar · OK8 A502 · binds LYS17, THR40, ALA41, GLY42, ASN43, GLU97, VAL99, ARG101 and 14 more
• 6YB9 · Human octameric paics in complex with saicar, AMP-pnp, and magnesium · OK8 A502 · binds LYS17, THR40, ALA41, GLY42, GLU97, VAL99, ARG101, THR105 and 14 more
• 7ALE · Crystal structure of human paics in complex with inhibitor 69 · OK8 A502 · binds LYS17, THR18, THR40, ALA41, GLY42, GLU97, VAL99, ARG101 and 15 more

Residues it binds most

ARG 10, LYS 10, ASP 10, THR 10, GLY 10, SER 10, PHE 10, ALA 10, GLU 10, MET 10 (residue and the binding sites it lines).

Found with

• EDO · 1,2-ethanediol
• ANP · Phosphoaminophosphonic acid-adenylate ester
• C2R · 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid
• RLK · 2-azanyl-~{N}-[2-bromanyl-5-[4-[3-(dimethylamino) propylsulfonyl]piperazin-1-yl]phenyl]-1,3-oxazole-4-carboxamide
• MG · Magnesium ion
• IMD · Imidazole