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Ligand · NLA

NLA · Naphthalen-1-yl-acetic acid

NLA, Naphthalen-1-yl-acetic acid (C12 H10 O2, 186.2 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with…

Component
NLA
Formula
C12 H10 O2
Class
ligand
Structures
8
PDB entries
4

Binding sites

NLA in 8 structures; the first of them:

  • 1LRH · Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid · NLA A5190 · binds ILE22, LEU25, TRP44, GLN46, ILE48, THR54, PRO55, HIS57 and 7 more
  • 2P1O · Mechanism of Auxin Perception by the TIR1 ubiquitin ligase · NLA B801 · binds HIS78, PHE79, PHE82, LEU378, PHE380, ARG403, LEU404, CYS405 and 8 more
  • 3N8I · Crystal structure of the A isoform of human cytoplasmic protein tyrosine phosphatase… · NLA A158 · binds GLN76, ILE77, THR78, LYS79, PHE82, ARG101, LYS102, GLN105 and 1 more
  • 4O1Y · Crystal structure of Porcine Pancreatic Phospholipase A2 in complex with… · NLA A201 · binds LEU2, PHE5, ARG6, ILE9, PRO18, LEU19, PHE22, ASN23 and 7 more
  • 1LRH · Crystal structure of auxin-binding protein 1 in complex with 1- naphthalene acetic acid · NLA A5190 · binds ILE22, LEU25, TRP44, GLN46, ILE48, THR54, PRO55, HIS57 and 7 more
  • 2P1O · Mechanism of auxin perception by the TIR1 ubiquitin ligase · NLA B801 · binds HIS78, PHE79, PHE82, LEU378, PHE380, ARG403, LEU404, CYS405 and 8 more
  • 3N8I · Crystal structure of the a isoform of human cytoplasmic protein tyrosine phosphatase… · NLA A158 · binds GLN76, ILE77, THR78, LYS79, PHE82, ARG101, LYS102, GLN105 and 1 more
  • 4O1Y · Crystal structure of porcine pancreatic phospholipase A2 in complex with… · NLA A201 · binds LEU2, PHE5, ARG6, ILE9, PRO18, LEU19, PHE22, ASN23 and 7 more

Residues it binds most

PHE 14, HIS 12, ILE 12, LEU 12, TRP 10, GLN 10, PRO 12, THR 10, GLU 8, ARG 6 (residue and the binding sites it lines).

Found with

  • IHP · Inositol hexakisphosphate
  • CA · Calcium ion
  • ZN · Zinc ion
  • BMA · beta-D-mannopyranose
  • MAN · alpha-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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