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Ligand · NFK

NFK · N'-Formylkynurenine

NFK, N'-Formylkynurenine (C11 H12 N2 O4, 236.2 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
NFK
Formula
C11 H12 N2 O4
Class
ligand
Structures
8
PDB entries
4

Binding sites

NFK in 8 structures; the first of them:

  • 5TI9 · Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural… · NFK C402 · binds PHE72, HIS76, PHE140, ARG144, LEU147, ALA150, SER151, GLY152 and 8 more
  • 7NGE · Crystal structure of L-Trp/Indoleamine 2,3-dioxygenagse 1 (hIDO1) complex with the… · NFK A502 · binds LEU211, HIS215, SER341, TYR345, GLN348, HIS215, HIS218, ASP219 and 1 more
  • 7P0N · Crystal structure of L-Trp/Indoleamine 2,3-dioxygenagse 1 (hIDO1) complex with the… · NFK A502 · binds LEU49, ILE50, GLY53, GLN54, LEU55, ARG56, TRP92, GLY93 and 6 more
  • 7P0R · Crystal structure of L-Trp/Indoleamine 2,3-dioxygenase (hIDO1) complex with the JK-loop… · NFK A506 · binds ASN63, MET64, ARG105, ASN106
  • 5TI9 · Crystal structure of human tdo in complex with TRP and dioxygen, northeast structural… · NFK C402 · binds PHE72, HIS76, PHE140, ARG144, LEU147, ALA150, SER151, GLY152 and 8 more
  • 7NGE · Crystal structure of L-TRP/INDOLEAMINE 2,3-dioxygenagse 1 (HIDO1) complex with the… · NFK A502 · binds LEU211, HIS215, SER341, TYR345, GLN348, HIS215, HIS218, ASP219 and 1 more
  • 7P0N · Crystal structure of L-TRP/INDOLEAMINE 2,3-dioxygenagse 1 (HIDO1) complex with the… · NFK A502 · binds LEU49, ILE50, GLY53, GLN54, LEU55, ARG56, TRP92, GLY93 and 6 more
  • 7P0R · Crystal structure of L-TRP/INDOLEAMINE 2,3-dioxygenase (HIDO1) complex with the jk-loop… · NFK A506 · binds ASN63, MET64, ARG105, ASN106

Residues it binds most

GLY 10, HIS 12, LEU 16, ARG 14, TYR 10, ASP 14, LYS 12, PHE 8, GLN 10, ALA 4 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe
  • TRP · Tryptophan
  • PO4 · Phosphate ion
  • GOL · Glycerol
  • CL · Chloride ion
  • OXY · Oxygen molecule
  • NA · Sodium ion

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