Ligand · MXA
MXA · 6-(2,5-dimethoxy-benzyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine
MXA, 6-(2,5-dimethoxy-benzyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine (C17 H19 N5 O2, 325.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the…
- Component
- MXA
- Formula
- C17 H19 N5 O2
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
MXA in 4 structures; the first of them:
- 1DLR · Methotrexate-resistant variants of human dihydrofolate reductase with substitution of… · MXA A188 · binds ILE7, VAL8, ALA9, PHE22, GLU30, PHE31, PHE34, THR56 and 7 more
- 1U71 · Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of… · MXA A187 · binds ILE7, VAL8, ALA9, GLY20, ASP21, ARG22, GLU30, PHE31 and 9 more
- 1DLR · Methotrexate-resistant variants of human dihydrofolate reductase with substitution of… · MXA A188 · binds ILE7, VAL8, ALA9, PHE22, GLU30, PHE31, PHE34, THR56 and 7 more
- 1U71 · Understanding the role of LEU22 variants in methotrexate resistance: comparison of… · MXA A187 · binds ILE7, VAL8, ALA9, GLY20, ASP21, ARG22, GLU30, PHE31 and 9 more
Residues it binds most
PHE 4, ILE 4, THR 4, VAL 4, ALA 4, ASN 4, GLU 4, PRO 4, SER 4, TYR 4 (residue and the binding sites it lines).
Found with
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