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Ligand · MGM

MGM · 2-[methyl-(5-geranyl-4-methyl-pent-3-enyl)-amino]-ethyl-diphosphate

MGM, 2-[methyl-(5-geranyl-4-methyl-pent-3-enyl)-amino]-ethyl-diphosphate (C19 H37 N O7 P2, 453.4 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
MGM
Formula
C19 H37 N O7 P2
Class
ligand
Structures
12
PDB entries
6

Binding sites

MGM in 12 structures; the first of them:

  • 1N4Q · Protein Geranylgeranyltransferase type-I Complexed with a GGPP Analog and a KKKSKTKCVIL… · MGM B1401 · binds LYS164, TYR166, LYS198, ASN199, TYR200, HIS201, THR49, PHE52 and 19 more
  • 1TNB · Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a substrate… · MGM B379 · binds LYS164, TYR166, LYS198, ASN199, TYR200, HIS201, THR49, PHE52 and 18 more
  • 1TNO · Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a… · MGM B380 · binds LYS164, TYR166, LYS198, ASN199, TYR200, HIS201, THR49, PHE52 and 19 more
  • 1TNU · Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a GCINCCKVL… · MGM B379 · binds LYS164, TYR166, LYS198, ASN199, TYR200, HIS201, THR49, PHE52 and 20 more
  • 1TNY · Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a… · MGM B380 · binds LYS164, TYR166, LYS198, ASN199, TYR200, HIS201, THR49, PHE52 and 19 more
  • 1TNZ · Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a RRCVLL… · MGM B379 · binds LYS164, TYR166, LYS198, ASN199, TYR200, HIS201, THR49, PHE52 and 19 more
  • 1N4Q · Protein geranylgeranyltransferase type-I complexed with a ggpp analog and a kkksktkcvil… · MGM B1401 · binds LYS164, TYR166, LYS198, ASN199, TYR200, HIS201, THR49, PHE52 and 19 more

Residues it binds most

TYR 72, LYS 72, PHE 72, CYS 72, ARG 72, HIS 72, THR 72, ASN 72, GLN 72, GLY 72 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • CL · Chloride ion
  • MES · 2-(N-morpholino)-ethanesulfonic acid
  • GER · Geran-8-yl geran

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