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Ligand · M7M

M7M · N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate)

M7M, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate) (C13 H23 N5 O11 P2, 487.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
M7M
Formula
C13 H23 N5 O11 P2
Class
ligand
Structures
4
PDB entries
2

Binding sites

M7M in 4 structures; the first of them:

  • 3JCM · Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP · M7M E201 · binds LYS324, ASN359, GLU362, LEU363, PHE391, U80, G81, A82 and 1 more
  • 3M94 · Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap · M7M A1 · binds TRP69, ASP103, MET114, TRP115, GLU116, ASN168, ARG170, LYS175 and 1 more
  • 3JCM · Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snrnp · M7M E201 · binds LYS324, ASN359, GLU362, LEU363, PHE391, U80, G81, A82 and 1 more
  • 3M94 · Complex crystal structure of ascaris suum EIF4E-3 with M2,2,7G cap · M7M A1 · binds TRP69, ASP103, MET114, TRP115, GLU116, ASN168, ARG170, LYS175 and 1 more

Residues it binds most

TRP 2, A 2, ASN 4, GLU 4, LYS 4, ARG 2, ASP 2, G 2, LEU 2, MET 2 (residue and the binding sites it lines).

Found with

  • ACE · Acetyl group
  • GTP · Guanosine-5'-triphosphate

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