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Ligand · LO3

LO3 · (1S,3S,4S,5S,7R,8S,9R,12E,14E,16R,17R,19R)-16-hydroxy-9-{(1S,2S,3S)-2-hydroxy-5-[(2S,4R,6S)-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]-1,3-dimethylpentyl}-3,5,7,17-tetramethoxy-8,14-dimethyl-11H-spiro[10,23-dioxabicyclo[17.3.1]tricosa-12,14,20-triene-4,2'-oxiran]-11-one

LO3, (1S,3S,4S,5S,7R,8S,9R,12E,14E,16R,17R,19R)-16-hydroxy-9-{(1S,2S,3S)-2-hydroxy-5-[(2S,4R,6S)-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]-1,3-dimethylpentyl}-3,5,7,17-tetramethoxy-8,14-dimethyl-11H-spiro[10,23-dioxabicyclo[17.3.1]tricosa…

Component
LO3
Formula
C42 H70 O12
Class
ligand
Structures
2
PDB entries
1

Binding sites

LO3 in 2 structures; the first of them:

  • 3M6G · Crystal structure of actin in complex with lobophorolide · LO3 A600 · binds TYR133, TYR143, ALA144, SER145, GLY146, ARG147, THR148, ILE345 and 13 more
  • 3M6G · Crystal structure of actin in complex with lobophorolide · LO3 A600 · binds TYR133, TYR143, ALA144, SER145, GLY146, ARG147, THR148, ILE345 and 13 more

Residues it binds most

ILE 4, LEU 4, SER 4, ASP 4, GLY 4, THR 4, TYR 4, ALA 4, ARG 4, MET 4 (residue and the binding sites it lines).

Found with

  • ATP · Adenosine-5'-triphosphate
  • CA · Calcium ion
  • MG · Magnesium ion

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