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Ligand · LII

LII · (Z)-6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine

LII, (Z)-6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (C18 H19 N5 O2, 337.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within…

Component
LII
Formula
C18 H19 N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

LII in 2 structures; the first of them:

  • 1KMV · Human dihydrofolate reductase complexed with NADPH and… · LII A201 · binds ILE7, VAL8, ALA9, LEU22, GLU30, PHE31, PHE34, THR56 and 7 more
  • 1KMV · Human dihydrofolate reductase complexed with NADPH and (Z)… · LII A201 · binds ILE7, VAL8, ALA9, LEU22, GLU30, PHE31, PHE34, THR56 and 7 more

Residues it binds most

ILE 2, PHE 2, THR 2, VAL 2, ALA 2, ASN 2, GLU 2, LEU 2, PRO 2, SER 2 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
  • SO4 · Sulfate ion
  • DMS · Dimethyl sulfoxide

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