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Ligand · LIH

LIH · 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine

LIH, 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (C18 H17 N7, 331.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the…

Component
LIH
Formula
C18 H17 N7
Class
ligand
Structures
2
PDB entries
1

Binding sites

LIH in 2 structures; the first of them:

  • 1KMS · Human dihydrofolate reductase complexed with NADPH and… · LIH A201 · binds ILE7, VAL8, ALA9, LEU22, GLU30, PHE31, PHE34, THR56 and 7 more
  • 1KMS · Human dihydrofolate reductase complexed with NADPH and 6… · LIH A201 · binds ILE7, VAL8, ALA9, LEU22, GLU30, PHE31, PHE34, THR56 and 7 more

Residues it binds most

ILE 2, PHE 2, THR 2, VAL 2, ALA 2, ASN 2, GLU 2, LEU 2, PRO 2, SER 2 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
  • SO4 · Sulfate ion

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