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Ligand · KAP

KAP · 7-keto-8-aminopelargonic acid

KAP, 7-keto-8-aminopelargonic acid (C9 H17 N O3, 187.2 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
KAP
Formula
C9 H17 N O3
Class
ligand
Structures
10
PDB entries
5

Binding sites

KAP in 10 structures; the first of them:

  • 1QJ3 · Crystal structure of 7,8-diaminopelargonic acid synthase in complex with… · KAP A1430 · binds TYR17, TRP52, TRP53, TYR144, ASP147, ALA217, LYS274, ARG391 and 4 more
  • 3DU4 · Crystal structure of 7-keto-8-aminopelargonic acid bound 7,8-diaminopelargonic acid… · KAP A451 · binds PHE17, VAL53, TRP54, TYR146, ASP149, PHE162, ALA223, LYS280 and 6 more
  • 3FMI · Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with… · KAP A430 · binds ASP142, LEU143, GLY144, THR145, LEU146, ASN147, ASN182, THR11 and 10 more
  • 4A0H · Structure of bifunctional DAPA aminotransferase-DTB synthetase from Arabidopsis thaliana… · KAP A1808 · binds PHE326, TRP369, TRP370, TYR473, ASP476, TYR489, ALA587, LYS644 and 6 more
  • 4CXQ · Mycobaterium tuberculosis transaminase BioA complexed with substrate KAPA · KAP A502 · binds TYR25, TRP64, TRP65, TYR157, ASP160, ALA226, LYS283, ARG400 and 5 more
  • 1QJ3 · Crystal structure of 7,8-diaminopelargonic acid synthase in complex with… · KAP A1430 · binds TYR17, TRP52, TRP53, TYR144, ASP147, ALA217, LYS274, ARG391 and 4 more
  • 3DU4 · Crystal structure of 7-keto-8-aminopelargonic acid bound 7,8- diaminopelargonic acid… · KAP A451 · binds PHE17, VAL53, TRP54, TYR146, ASP149, PHE162, ALA223, LYS280 and 6 more
  • 3FMI · Crystal structure of mycobacterium tuberculosis dethiobiotin synthetase complexed with… · KAP A430 · binds ASP142, LEU143, GLY144, THR145, LEU146, ASN147, ASN182, THR11 and 10 more
  • 4A0H · Structure of bifunctional dapa aminotransferase-dtb synthetase from arabidopsis thaliana… · KAP A1808 · binds PHE326, TRP369, TRP370, TYR473, ASP476, TYR489, ALA587, LYS644 and 6 more
  • 4CXQ · Mycobaterium tuberculosis transaminase bioa complexed with substrate kapa · KAP A502 · binds TYR25, TRP64, TRP65, TYR157, ASP160, ALA226, LYS283, ARG400 and 5 more

Residues it binds most

GLY 26, THR 18, TYR 16, ALA 26, LEU 18, PRO 20, TRP 16, ARG 26, ASP 22, PHE 16 (residue and the binding sites it lines).

Found with

  • PLP · Pyridoxal-5'-phosphate
  • NA · Sodium ion
  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol
  • PEG · Di(hydroxyethyl)ether
  • TLA · L(+)-tartaric acid

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