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Ligand · KA5

KA5 · 5-chloro-N~6~-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine

KA5, 5-chloro-N~6~-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine (C17 H18 Cl N5 O2, 359.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues it…

Component
KA5
Formula
C17 H18 Cl N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

KA5 in 2 structures; the first of them:

  • 3JSU · Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate… · KA5 A609 · binds ILE14, CYS15, ALA16, LEU46, ASP54, MET55, PHE58, ASN108 and 8 more
  • 3JSU · Quadruple MUTANT(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate… · KA5 A609 · binds ILE14, CYS15, ALA16, LEU46, ASP54, MET55, PHE58, ASN108 and 8 more

Residues it binds most

LEU 4, ILE 4, PHE 4, ALA 4, ASN 4, ASP 4, CYS 4, MET 4, PRO 4, SER 4 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
  • UMP · 2'-deoxyuridine 5'-monophosphate

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