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Ligand · ITP

ITP · Phosphoric acid mono-(2,3,4,6-tetrahydroxy-5-phosphonooxy-cyclohexyl) ester

ITP, Phosphoric acid mono-(2,3,4,6-tetrahydroxy-5-phosphonooxy-cyclohexyl) ester (C6 H14 O12 P2, 340.1 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å…

Component
ITP
Formula
C6 H14 O12 P2
Class
ligand
Structures
6
PDB entries
3

Binding sites

ITP in 6 structures; the first of them:

  • 1HYI · Solution structure of the EEA1 fyve domain complexed with inositol 1,3-bisphosphate · ITP A68 · binds ARG25, HIS26, HIS27, ARG29, ILE34, ARG54
  • 1JOC · EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate · ITP A101 · binds TRP1349, ASP1352, ARG1370, ARG1371, HIS1372, HIS1373, ARG1375, ARG1400
  • 4AVX · Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) bound to an IP2… · ITP A1227 · binds TRP160, ARG178, LYS179, HIS180, HIS181, ARG183, ARG210
  • 1HYI · Solution structure of the EEA1 fyve domain complexed with inositol 1, 3-bisphosphate · ITP A68 · binds ARG25, HIS26, HIS27, ARG29, ILE34, ARG54
  • 1JOC · EEA1 homodimer of C-terminal fyve domain bound to inositol 1,3-diphosphate · ITP A101 · binds TRP1349, ASP1352, ARG1370, ARG1371, HIS1372, HIS1373, ARG1375, ARG1400
  • 4AVX · Hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an IP2… · ITP A1227 · binds TRP160, ARG178, LYS179, HIS180, HIS181, ARG183, ARG210

Residues it binds most

ARG 8, HIS 8, TRP 6, ASP 4, ILE 2, LYS 2 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • EDO · 1,2-ethanediol

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