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Ligand · HPM

HPM · N-{5-[(7-{[(2S)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide

HPM, N-{5-[(7-{[(2S)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide (C28 H31 N7 O4, 529.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
HPM
Formula
C28 H31 N7 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

HPM in 2 structures; the first of them:

  • 2C6E · Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl… · HPM A1389 · binds ARG136, LEU138, VAL146, ALA159, LYS161, LEU177, GLU180, VAL181 and 18 more
  • 2C6E · Aurora a kinase activated mutant (T287D) in complex with a 5-aminopyrimidinyl quinazoline… · HPM A1389 · binds ARG136, LEU138, VAL146, ALA159, LYS161, LEU177, GLU180, VAL181 and 18 more

Residues it binds most

LEU 4, ALA 4, GLU 4, VAL 4, ARG 4, GLY 4, ASP 4, GLN 4, LYS 4, PRO 4 (residue and the binding sites it lines).

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