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Ligand · HGG

HGG · (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide

HGG, (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid…

Component
HGG
Formula
C26 H42 N7 O20 P3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

HGG in 2 structures; the first of them:

  • 3MP3 · Crystal Structure of Human Lyase in complex with inhibitor HG-CoA · HGG B399 · binds ARG41, ASP42, GLN45, PHE76, VAL77, SER78, PRO79, LYS80 and 19 more
  • 3MP3 · Crystal structure of human lyase in complex with inhibitor hg-CoA · HGG B399 · binds ARG41, ASP42, GLN45, PHE76, VAL77, SER78, PRO79, LYS80 and 19 more

Residues it binds most

ASN 2, HIS 2, ARG 2, GLY 2, LYS 2, PHE 2, PRO 2, SER 2, VAL 2, ASP 2 (residue and the binding sites it lines).

Found with

  • 3HG · 3-hydroxypentanedioic acid
  • MG · Magnesium ion

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