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Ligand · HCU

HCU · [(2R)-4-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-2-(hydroxymethyl)butyl] dihydrogen phosphate

HCU, [(2R)-4-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-2-(hydroxymethyl)butyl] dihydrogen phosphate (C10 H16 N5 O6 P, 333.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its…

Component
HCU
Formula
C10 H16 N5 O6 P
Class
ligand
Structures
4
PDB entries
2

Binding sites

HCU in 4 structures; the first of them:

  • 7DOI · Structure of COVID-19 RNA-dependent RNA polymerase bound to penciclovir. · HCU P1201 · binds LYS545, ASP623, SER682, THR687, ASN691, SER759, ASP760, U20 and 2 more
  • 7DOK · Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to… · HCU P1201 · binds U20, U10, A11, LYS545, ASP623, SER682, THR687, ASN691 and 2 more
  • 7DOI · Structure of COVID-19 RNA-dependent RNA polymerase bound to penciclovir. · HCU P1201 · binds LYS545, ASP623, SER682, THR687, ASN691, SER759, ASP760, U20 and 2 more
  • 7DOK · Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to… · HCU P1201 · binds U20, U10, A11, LYS545, ASP623, SER682, THR687, ASN691 and 2 more

Residues it binds most

ASP 4, SER 4, U 4, A 4, ASN 4, LYS 4, THR 4 (residue and the binding sites it lines).

Found with

  • POP · Pyrophosphate 2-
  • MG · Magnesium ion
  • ZN · Zinc ion

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