GL1X · GenesisL1 explorer

Ligand · H2T

H2T · 1-[6-[4-(5-chloranyl-6-methyl-1~{H}-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]propan-1-one

H2T, 1-[6-[4-(5-chloranyl-6-methyl-1~{H}-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]propan-1-one (C29 H30 Cl N7 O, 528.1 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
H2T
Formula
C29 H30 Cl N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

H2T in 2 structures; the first of them:

  • 7R0M · KRasG12C in complex with GDP and JDQ443 · H2T A1003 · binds VAL9, GLY10, CYS12, LYS16, PRO34, THR58, ALA59, GLY60 and 16 more
  • 7R0M · KRASG12C in complex with GDP and JDQ443 · H2T A1003 · binds VAL9, GLY10, CYS12, LYS16, PRO34, THR58, ALA59, GLY60 and 16 more

Residues it binds most

GLN 4, GLU 4, ARG 4, GLY 4, TYR 4, ALA 4, HIS 2, VAL 4, ASP 4, CYS 4 (residue and the binding sites it lines).

Found with

  • GDP · Guanosine-5'-diphosphate
  • MG · Magnesium ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.