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Ligand · GW5

GW5 · (2E)-3-{4-[(1E)-1,2-diphenylbut-1-enyl]phenyl}acrylic acid

GW5, (2E)-3-{4-[(1E)-1,2-diphenylbut-1-enyl]phenyl}acrylic acid (C25 H22 O2, 354.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
GW5
Formula
C25 H22 O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

GW5 in 4 structures; the first of them:

  • 1R5K · Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638 · GW5 A600 · binds MET343, LEU346, THR347, ALA350, ASP351, GLU353, TRP383, LEU384 and 15 more
  • 5AAV · Optimization of a novel binding motif to to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-m… · GW5 A1552 · binds MET343, LEU346, THR347, LEU349, ALA350, ASP351, GLU353, TRP383 and 15 more
  • 1R5K · Human estrogen receptor alpha ligand-binding domain in complex with GW5638 · GW5 A600 · binds MET343, LEU346, THR347, ALA350, ASP351, GLU353, TRP383, LEU384 and 15 more
  • 5AAV · Optimization of a novel binding motif to to (E)-3-(3,5… · GW5 A1552 · binds MET343, LEU346, THR347, LEU349, ALA350, ASP351, GLU353, TRP383 and 15 more

Residues it binds most

LEU 10, MET 10, PHE 10, GLU 10, ALA 10, GLY 10, HIS 10, ILE 10, THR 10, TRP 10 (residue and the binding sites it lines).

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