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Ligand · GOZ

GOZ · (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[[2,6-bis(azanyl)pyridin-4-yl]methyl]pyrrolidine-2-carboxamide

GOZ, (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[[2,6-bis(azanyl)pyridin-4-yl]methyl]pyrrolidine-2-carboxamide (C20 H26 N6 O2, 382.5 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding…

Component
GOZ
Formula
C20 H26 N6 O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

GOZ in 4 structures; the first of them:

  • 6HSX · Thrombin in Complex with a D-Phe-Pro-diaminopyridine derivative · GOZ H309 · binds HIS57, TYR60A, TRP60D, GLU97A, ASN98, LEU99, ILE174, ASP189 and 12 more
  • 6T0M · Cationic Trypsin in Complex with a D-Phe-Pro-diaminopyridine derivative · GOZ A305 · binds HIS57, LEU99, ASP189, SER190, CYS191, GLN192, SER195, VAL213 and 9 more
  • 6HSX · Thrombin in complex with a D-phe-pro-diaminopyridine derivative · GOZ H309 · binds HIS57, TYR60A, TRP60D, GLU97A, LEU99, ILE174, ASP189, ALA190 and 10 more
  • 6T0M · Cationic trypsin in complex with a D-phe-pro-diaminopyridine derivative · GOZ A305 · binds HIS57, LEU99, ASP189, SER190, CYS191, GLN192, SER195, VAL213 and 6 more

Residues it binds most

GLY 4, SER 4, CYS 4, TRP 4, GLU 2, VAL 4, ASP 4, HIS 4, LEU 4, TYR 3 (residue and the binding sites it lines).

Found with

  • DMS · Dimethyl sulfoxide
  • CA · Calcium ion
  • NA · Sodium ion
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • PO4 · Phosphate ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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