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Ligand · GF6

GF6 · 1-[3-(trifluoromethyl)phenyl]urea

GF6, 1-[3-(trifluoromethyl)phenyl]urea (C8 H7 F3 N2 O, 204.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
GF6
Formula
C8 H7 F3 N2 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

GF6 in 2 structures; the first of them:

  • 7CTZ · Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS)… · GF6 A703 · binds ILE14, CYS15, ALA16, LEU46, ASP54, PHE58, ILE164
  • 7CTZ · Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts)… · GF6 A703 · binds ILE14, CYS15, ALA16, LEU46, ASP54, PHE58, ILE164

Residues it binds most

ILE 2, ALA 2, ASP 2, CYS 2, LEU 2, PHE 2 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
  • UMP · 2'-deoxyuridine 5'-monophosphate

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