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Ligand · GF3

GF3 · spiro[1H-2-benzofuran-3,4'-piperidine]

GF3, spiro[1H-2-benzofuran-3,4'-piperidine] (C12 H15 N O, 189.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
GF3
Formula
C12 H15 N O
Class
ligand
Structures
2
PDB entries
1

Binding sites

GF3 in 2 structures; the first of them:

  • 7CTY · Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS)… · GF3 A702 · binds ALA16, LEU46, ASP54, MET55, PHE58, SER108, SER111, ILE112 and 1 more
  • 7CTY · Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts)… · GF3 A702 · binds LEU46, ASP54, MET55, PHE58, SER108, SER111, ILE112, ILE164

Residues it binds most

ILE 4, SER 4, ASP 4, LEU 4, MET 4, PHE 4, ALA 3 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
  • PO4 · Phosphate ion

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