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Ligand · G8W

G8W · (2~{S})-2-[[(2~{S})-6-[(6-fluoranylpyridin-3-yl)amino]-1-oxidanyl-1,6-bis(oxidanylidene)hexan-2-yl]carbamoylamino]pentanedioic acid

G8W, (2~{S})-2-[[(2~{S})-6-[(6-fluoranylpyridin-3-yl)amino]-1-oxidanyl-1,6-bis(oxidanylidene)hexan-2-yl]carbamoylamino]pentanedioic acid (C17 H21 F N4 O8, 428.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
G8W
Formula
C17 H21 F N4 O8
Class
ligand
Structures
2
PDB entries
1

Binding sites

G8W in 2 structures; the first of them:

  • 6HKJ · X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a… · G8W A818 · binds LYS207, VAL208, PHE209, ARG210, ASN257, ASP387, GLU424, GLU425 and 16 more
  • 6HKJ · X-ray structure of human glutamate carboxypeptidase II (gcpii) in complex with a… · G8W A818 · binds LYS207, VAL208, PHE209, ARG210, ASN257, ASP387, GLU424, GLU425 and 16 more

Residues it binds most

ARG 2, ASN 2, GLY 2, ASP 2, GLU 2, LYS 2, PHE 2, SER 2, TYR 2, HIS 2 (residue and the binding sites it lines).

Found with

  • TAM · Tris(hydroxyethyl)aminomethane
  • CA · Calcium ion
  • ZN · Zinc ion
  • BMA · beta-D-mannopyranose
  • MAN · alpha-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CL · Chloride ion

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