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Ligand · FIS

FIS · (2S,4R)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione

FIS, (2S,4R)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione (C12 H10 F N3 O4, 279.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
FIS
Formula
C12 H10 F N3 O4
Class
ligand
Structures
4
PDB entries
2

Binding sites

FIS in 4 structures; the first of them:

  • 1X98 · Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat… · FIS A1320 · binds TRP20, LYS21, ASP216, PRO218, TRP219
  • 3BCJ · Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat… · FIS A320 · binds TRP20, LYS21, ASP216, PRO218, TRP219
  • 1X98 · Crystal structure of aldose reductase complexed with 2S4R (stereoisomer of fidarestat… · FIS A1320 · binds TRP20, LYS21, ASP216, PRO218, TRP219
  • 3BCJ · Crystal structure of aldose reductase complexed with 2S4R (stereoisomer of fidarestat… · FIS A320 · binds TRP20, LYS21, ASP216, PRO218, TRP219

Residues it binds most

TRP 4, ASP 4, LYS 4, PRO 4 (residue and the binding sites it lines).

Found with

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate
  • CIT · Citric acid

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