GL1X · GenesisL1 explorer

Ligand · EV9

EV9 · [(2~{R})-3-[[(2~{S})-3-[(2~{S})-2,6-bis(azanyl) hexanoyl]oxy-2-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-2-hexadecanoyloxy-propyl] hexadecanoate

EV9, [(2~{R})-3-[[(2~{S})-3-[(2~{S})-2,6-bis(azanyl) hexanoyl]oxy-2-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-2-hexadecanoyloxy-propyl] hexadecanoate (C44 H87 N2 O11 P, 851.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
EV9
Formula
C44 H87 N2 O11 P
Class
ligand
Structures
2
PDB entries
2

Binding sites

EV9 in 2 structures; the first of them:

  • 6LVF · Cryo-EM structure of the multiple peptide resistance factor (mprf) loaded with one… · EV9 B1001 · binds LEU23, LEU24, GLY116, ASN117, ALA126, THR152, PHE155, GLY156 and 14 more
  • 7DUW · Cryo-EM structure of the multiple peptide resistance factor (mprf) loaded with two… · EV9 A902 · binds SER81, TYR113, GLY116, ASN117, THR152, PHE155, GLY156, ALA160 and 15 more

Residues it binds most

ALA 6, LEU 6, GLY 6, VAL 6, ILE 6, PHE 6, TYR 4, SER 6, ASN 6, THR 6 (residue and the binding sites it lines).

Found with

  • LHG · 1,2-dipalmitoyl-phosphatidyl-glycerole
  • PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate
  • J4U · (2~{R},3~{S},4~{S},5~{S},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{S},4~{R},5~{R},6~{R})-2-(hydroxymethyl)-6-[2-[[(2~{R},3~{S},4~{R},5~{R},6~{S})-6-(hydroxymethyl)-5-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,4-bis(oxidanyl)oxan-2-yl]oxymethyl]-4-[(1~{R},2~{R}, 4~{S},5'~{R},6~{R},7~{R},8~{R},9~{S},12~{S},13~{R}, 16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxy-butoxy]-4,5-bis(oxidanyl)oxa
  • LMT · Dodecyl-beta-D-maltoside

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