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Ligand · EV6

EV6 · (3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]pentanamide

EV6, (3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]pentanamide (C22 H29 Cl N4 O, 400.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
EV6
Formula
C22 H29 Cl N4 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

EV6 in 2 structures; the first of them:

  • 3S2O · Fragment based discovery and optimisation of bace-1 inhibitors · EV6 A393 · binds LEU30, ASP32, GLY34, SER35, VAL69, TYR71, TRP76, PHE108 and 6 more
  • 3S2O · Fragment based discovery and optimisation of bace-1 inhibitors · EV6 A393 · binds LEU30, ASP32, GLY34, SER35, VAL69, TYR71, TRP76, PHE108 and 6 more

Residues it binds most

ASP 2, GLY 2, TRP 2, TYR 2, ILE 2, LEU 2, PHE 2, SER 2, THR 2, VAL 2 (residue and the binding sites it lines).

Found with

  • IOD · Iodide ion

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