Ligand · EQK
EQK · N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide
EQK, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide (C20 H17 F3 N6 O3 S, 478.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (3 PDB entries). Every…
- Component
- EQK
- Formula
- C20 H17 F3 N6 O3 S
- Class
- ligand
- Structures
- 3
- PDB entries
- 3
Binding sites
EQK in 3 structures; the first of them:
- 7XJ0 · Structure of human TRPV3 in complex with Trpvicin · EQK B1406 · binds VAL596, PHE597, GLY600, PHE601, ALA604, PHE656, THR660, ILE663 and 8 more
- 7XJ1 · Structure of human TRPV3_G573S in complex with Trpvicin in C2 symmetry · EQK B1602 · binds LEU635, THR636, ILE637, GLY638, VAL662, THR665, PHE666, LEU669 and 7 more
- 7XJ2 · Structure of human TRPV3_G573S in complex with Trpvicin in C4 symmetry · EQK B1101 · binds LEU553, MET555, ALA556, LEU557, TRP559, ALA560, ILE583, VAL596 and 6 more
Residues it binds most
LEU 18, PHE 18, ALA 12, ILE 17, VAL 18, THR 16, GLY 15, TRP 12, MET 8, TYR 1 (residue and the binding sites it lines).
Found with
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
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