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Ligand · E78

E78 · ~{N}-[5-[2-[(1~{S})-1-cyclopropylethyl]-7-methyl-1-oxidanylidene-3~{H}-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide

E78, ~{N}-[5-[2-[(1~{S})-1-cyclopropylethyl]-7-methyl-1-oxidanylidene-3~{H}-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide (C20 H23 N3 O2 S, 369.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
E78
Formula
C20 H23 N3 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

E78 in 2 structures; the first of them:

  • 6FTN · mPI3Kd IN COMPLEX WITH AZ2 · E78 A1101 · binds TRP760, ILE777, LYS779, LEU784, ASP787, TYR813, CYS815, ILE825 and 6 more
  • 6FTN · MPI3KD in complex with AZ2 · E78 A1101 · binds TRP760, ILE777, LYS779, LEU784, ASP787, TYR813, CYS815, ILE825 and 6 more

Residues it binds most

ILE 2, VAL 2, ASP 2, CYS 2, GLU 2, LEU 2, LYS 2, MET 2, SER 2, TRP 2 (residue and the binding sites it lines).

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