Ligand · E67
E67 · 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine
E67, 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine (C31 H47 N7 O2, 549.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every…
- Component
- E67
- Formula
- C31 H47 N7 O2
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
E67 in 4 structures; the first of them:
- 3MO2 · human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 · E67 A1 · binds TYR1124, ASP1131, ALA1134, ASP1135, VAL1136, ARG1137, GLU1138, ASP1140 and 11 more
- 3U78 · E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase · E67 A707 · binds ILE195, GLN200, ASP202, ILE226, TYR278, THR279, ASP280, HIS282 and 6 more
- 3MO2 · Human G9A-like (glp, also known as EHMT1) in complex with inhibitor E67 · E67 A1 · binds TYR1124, ASP1131, ALA1134, ASP1135, VAL1136, ARG1137, GLU1138, ASP1140 and 11 more
- 3U78 · E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 jumonji demethylase · E67 A707 · binds ILE195, GLN200, ASP202, ILE226, TYR278, THR279, ASP280, HIS282 and 6 more
Residues it binds most
ASP 10, PHE 10, TYR 10, ARG 8, ILE 10, LYS 10, ALA 8, CYS 8, LEU 8, SER 8 (residue and the binding sites it lines).
Found with
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