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Ligand · DX6

DX6 · 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

DX6, 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (C14 H14 N4 O, 254.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the…

Component
DX6
Formula
C14 H14 N4 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

DX6 in 2 structures; the first of them:

  • 3JQB · Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary… · DX6 A270 · binds ARG14, SER95, ALA96, PHE97, ASP161, CYS168, TYR174, GLY205 and 6 more
  • 3JQB · Crystal structure of pteridine reductase 1 (PTR1) from trypanosoma brucei in ternary… · DX6 A270 · binds ARG14, SER95, ALA96, PHE97, ASP161, CYS168, TYR174, GLY205 and 6 more

Residues it binds most

LEU 6, ALA 6, ARG 6, ASP 6, GLY 6, MET 6, PHE 6, PRO 6, SER 6, TRP 6 (residue and the binding sites it lines).

Found with

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate
  • DTT · 2,3-dihydroxy-1,4-dithiobutane

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